Melatonin evidence, 2001
Zhdanova IV, Wurtman RJ, et al., Journal of Clinical Endocrinology & Metabolism, 2001 — crossover RCT of 0.1–3 mg melatonin in older adults
- Grade
- Design
- crossover rct
- Year
- 2001
- Participants
- 30
- Ingredient
- Melatonin
- Goal
- Sleep
Effect
Doses as low as 0.3 mg improved sleep efficiency comparably to 3 mg; higher doses produced more next-day carryover without better sleep.
Limitations and notes
Why our dose guidance starts at 0.5 mg rather than the retail default of 5–10 mg.